Cited by: 19Publish Year: 2017Author: Adam T. Waickman, Davinna L. Ligons, SuJin Hwang, Joo-Young Park, Vanja Lazarevic, Noriko Sato, Chan...CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans. T cells are both producers and consumers of cytokines, and autocrine cytokine signaling plays a critical role in T cell immunity.sp.info CD4 effector T cell differentiation is controlled by IL-15 ...Nov 01, 2017 · In the same vein, CD4 T cells from IL-15-deficient mice exhibited dysregulated effector functions, which supported an autocrine role for IL-15 in effector T cell differentiation , . Thus, CD4 T cell-derived IL-15 is potentially an important mechanism that controls CD4 T helper function.Cited by: 19Publish Year: 2017Author: Adam T. Waickman, Davinna L. Ligons, SuJin Hwang, Joo-Young Park, Vanja Lazarevic, Noriko Sato, Chan...sp.info CD4 effector T cell differentiation is controlled by IL-15 ...Aug 12, 2017 · CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans.Cited by: 19Publish Year: 2017Author: Adam T. Waickman, Davinna L. Ligons, SuJin Hwang, Joo-Young Park, Vanja Lazarevic, Noriko Sato, Chan...sp.info CD4 effector T cell differentiation is controlled by IL-15 ...Consequently, IL-15Rα-bound IL-15, but not free IL-15, suppressed Th17 cell differentiation and induced Treg cell generation. Collectively, these results reveal the absence of an IL-15 autocrine loop in CD4 T cells and strongly suggest that IL-15 trans -presentation by non-CD4 T cells is the primary mechanism via which IL-15 controls CD4 effector T cell differentiation.Cited by: 19Publish Year: 2017Author: Adam T. Waickman, Davinna L. Ligons, SuJin Hwang, Joo-Young Park, Vanja Lazarevic, Noriko Sato, Chan...
PDF | T cells are both producers and consumers of cytokines, and autocrine cytokine signaling plays a critical role in T cell immunity. IL-15 is a... | Find, read and cite all the research you ...sp.info Differentiation of Effector CD4 T Cell PopulationsIt was subsequently shown that Th1 cells could be differentiated in vitro from naive CD4 T cells if IL-4 was neutralized and IL-12 was added to the culture . Experiments in which single naive CD4 T cells were primed in vitro indicate that individual CD4 T cells can be made to differentiate into Th1 or Th2 cells (8–10). There was considerable controversy as to whether the inducing …Cited by: 3412Publish Year: 2010Author: Jinfang Zhu, Hidehiro Yamane, William E. Paulsp.info CD4 effector T cell differentiation is controlled by IL-15 ...Here we examined IL-15 expression and signaling upon effector T cell differentiation in mice, and, surprisingly, found that CD4 T cells did not express IL-15. CD4 T cells lacked Il15 gene reporter activity, did not contain IL-15 transcripts, and did not produce IL-15Rα, the proprietary IL-15 receptor required for IL-15 trans-presentation.sp.info CD4+T Cells: Differentiation and FunctionsMar 14, 2012 · CD4 + T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4 + T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been …Cited by: 852Publish Year: 2012Author: Rishi Vishal Luckheeram, Rui Zhou, Asha Devi Verma, Bing Xia
The main subsets of CD4+ regulatory T (Tr) cells are the CD4+ CD25+ Tr cells and the type 1 regulatory (Tr1) cells. Both subsets are essential for the maintenance of peripheral tolerance. CD4+ CD25+ Tr cells control immune homeostasis (e.g., in autoimmunity) mainly by cell contact-dependent interact …sp.info Role of CD4+ T Cells in the Control of Viral Infections ...Jan 07, 2021 · The “Exhaustion” T Cell Differentiation Program. CD4+ T cells are essential in the setting of chronic viral infections, as demonstrated most clearly in HIV infection, where the progressive depletion of CD4+ helper T cells is accompanied by a progressive dysfunction of CD8+ T cells, which adopt an exhausted phenotype characterized by the expression of …Cited by: 3Publish Year: 2021Author: Jérôme Kervevan, Lisa A. Chakrabarti, Lisa A. Chakrabartisp.info Pleiotropic Effects of IL-33 on CD4 + T Cell ...Pleiotropic Effects of IL-33 on CD4 + T Cell Differentiation and Effector Functions - PubMed. IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a promoter of type 2 immune responses.Cited by: 25Publish Year: 2019Author: Fernando Alvarez, Jörg H. Fritz, Ciriaco A. Piccirillosp.info Neoantigen-driven B cell and CD4 T follicular helper cell ...Nov 30, 2021 · B cells promote the differentiation of tumor-specific CD4 T follicular helper cells in a neoantigen-dependent manner, which in turn enhance CD8 T cell effector functions by producing IL-21 and drive anti-tumor immunity in a murine model of lung adenocarcinoma.
May 28, 2009 · Like IL-12, IL-27 induces Th1 differentiation from mouse and human naïve CD4 T cells; like IL-18, IL-27 synergizes with IL-12 to potently induce IFN-γ production (Pflanz et al., 2002). IL-27 is composed of EBI3 (Epstein-Barr virus-induced gene 3), a p40 homolog, and a novel subunit, p28.Cited by: 281Publish Year: 2009Author: Yisong Y. Wan, Richard A. Flavell, Richard A. Flavellsp.info Altered effector CD4+ T cell function in IL-21R-/- CD4+ T ...After transplantation, CD4(+) T cell numbers in the spleen were reduced, and MLR and cytokine production by CD4(+) T cells were impaired. These results suggest that IL-21 might promote GVHD through enhanced production of effector CD4(+) T cells.sp.info Plasticity of CD4+ T Cell Lineage Differentiation: ImmunityThe differentiation of naive CD4+ T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ, whereas Th2 cells express IL-4. The discovery and investigation of two other CD4+ T cell subsets, induced regulatory T (iTreg) cells and Th17 cells, has led to a rethinking of the notion that …Cited by: 1748Publish Year: 2009Author: Liang Zhou, Mark M.W. Chong, Dan R. Littmansp.info CD4+CD25+ regulatory T cells control CD8+ T-cell effector ...May 03, 2011 · Furthermore, a regulatory loop exists between Treg and CD8+ effector T cells, where IL-2 produced during CD8+ T-cell effector differentiation promotes Treg expansion. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis | PNASCited by: 185Publish Year: 2011Author: Alice McNally, Geoffrey R. Hill, Tim Sparwasser, Ranjeny Thomas, Raymond J. SteptoeEstimated Reading Time: 10 mins
Cytokines have long been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our lab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation.Cited by: 521Publish Year: 2009Author: Oliver Dienz, Mercedes Rinconsp.info DNA Methylation and Immune Memory ResponseAdditionally, in human cells, the transcriptional factor CREM-α mediates the epigenetic remodelling of the cytokines IL-2 and IL-17A genes during CD4 T cell differentiation, favouring memory effector cells. DNMT3A is important in the control of IL-2 and IL-17A expression in memory CD4 T cells .sp.info Inhibitory Phenotype of HBV-Specific CD4+ T-Cells Is ...Aug 21, 2014 · Results. CD4 + T-cell responses during chronic HBV infection was characterized by reduced Tetramer + CD4 + T-cell frequencies, effector memory phenotype, sustained PD-1 but low levels of CTLA-4, TIM-3, KLRG1 and CD244 expression. PD-1 blockade revealed individualized patterns of in vitro responsiveness with partly increased IFN-γ, IL-2 and TNF-α …sp.info Frontiers | Continuous Modeling of T CD4 Lymphocyte ...T CD4+ cells are central to the adaptive immune response against pathogens. Their activation is induced by the engagement of the T-cell receptor by antigens, and of co-stimulatory receptors by molecules also expressed on antigen presenting cells. Then, a complex network of intracellular events reinforce, diversify and regulate the initial signals, including dynamic metabolic …
These differentiation programs are controlled by cytokines produced by innate immune cells, such as IL-12 and IFN-γ, which are important for Th1 cell differentiation, and IL-4, which is crucial for Th2 cell differentiation.Cited by: 1748Publish Year: 2009Author: Liang Zhou, Mark M.W. Chong, Dan R. Littmansp.info Neoantigen-driven B cell and CD4 T follicular helper cell ...Nov 30, 2021 · The mechanisms of how CD4 T cells provide necessary help to CD8 T cells remain uncertain, but one proposal involves CD4 T cells providing IL-21, which drives cytolytic effector CD8 T cell differentiation and prevents T cell exhaustion (Elsaesser et al., 2009; Fröhlich et al., 2009; Ren et al., 2020; Snell et al., 2018; Xin et al., 2015; Yi et ...sp.info TCR signal quantity and quality in CD4+ T cell differentiationThe conventional model of CD4 + T cell differentiation posits that TCR signaling triggers naïve CD4 + T cells to proliferate and differentiate into specialized effector cells in a process that is guided by cytokines produced by other cells. TCR signaling, together with interleukin 12 (IL-12) or type 1 interferon (IFN) [. 4.Cited by: 129Publish Year: 2014Author: Noah J. Tubo, Marc K. Jenkinssp.info Th17: An Effector CD4 T Cell Lineage with Regulatory T ...The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity but substantial plasticity for development down distinct effector or regulatory lineages, contingent upon signals from cells of the innate immune system. The range of identified effector CD4 T cell lineages has recently expanded with description of an IL-17-producing subset, called Th17, …Cited by: 1987Publish Year: 2006Author: Casey T. Weaver, Laurie E. Harrington, Paul R. Mangan, Maya Gavrieli, Kenneth M. Murphy
Apr 04, 2013 · Differentiation of CD4+ T cells into effector or regulatory phenotypes is tightly controlled by the cytokine milieu, complex intracellular signaling networks and numerous transcriptional regulators. We combined experimental approaches and computational modeling to investigate the mechanisms controlling differentiation and plasticity of CD4+ T ...Cited by: 99Publish Year: 2013Author: Adria Carbo, Raquel Hontecillas, Barbara Kronsteiner, Monica Viladomiu, Mireia Pedragosa, Pinyi Lu, ...Estimated Reading Time: 12 minssp.info Chapter 10: Differentiation and Functions of CD4 Helper T ...Start studying Chapter 10: Differentiation and Functions of CD4 Helper T Cells. Learn vocabulary, terms, and more with flashcards, games, and other study tools.sp.info CD4+CD25+ regulatory T cells control CD8+ T-cell effector ...Apr 18, 2011 · Here we demonstrate that CD4(+)CD25(+) Treg, by critically regulating IL-2 homeostasis, modulate CD8(+) T-cell effector differentiation. Expansion and effector differentiation of CD8(+) T cells is promoted by autocrine IL-2 but, by competing for IL-2, Treg limit CD8(+) effector differentiation.Cited by: 185Publish Year: 2011Author: Alice McNally, Geoffrey R. Hill, Tim Sparwasser, Ranjeny Thomas, Raymond J. Steptoesp.info regulatory T cells control CD8 effector differentiation by ...CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis Alice McNallya, Geoffrey R. Hillb, Tim Sparwasserc, Ranjeny Thomasa, and Raymond J. Steptoea,1 aUniversity of Queensland Diamantina Institute, University of Queensland, Brisbane 4072, Australia; bQueensland Institute of Medical Research, Brisbane …Cited by: 185Publish Year: 2011Author: Alice McNally, Geoffrey R. Hill, Tim Sparwasser, Ranjeny Thomas, Raymond J. Steptoe
Interleukin-2 (IL-2)–the first cytokine to be identified and characterized more than three decades ago—has emerged as a pleiotropic player in a variety of seemingly paradoxical immune functions. Originally discovered for its immunoenhancing role of promoting T cell expansion during mitogenic stimulation, IL-2 is also implicated in activation-induced cell death (AICD). Likewise, IL-2 promotes a variety of effec…See more on frontiersin.orgCited by: 52Publish Year: 2018Author: Vandana Kalia, Vandana Kalia, Surojit SarkarSome results are removed in response to a notice of local law requirement. For more information, please see here.
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